Researchers have just lately recognized and succeeded in synthesizing conolidine, a organic compound that exhibits promise as a potent analgesic agent with a far more favorable security profile. Even though the specific mechanism of action remains elusive, it truly is currently postulated that conolidine may have various biologic targets. Presently… Read More

When the opiate receptor relies on G protein coupling for signal transduction, this receptor was discovered to make use of arrestin activation for internalization in the receptor. Or else, the receptor promoted no other signaling cascades (59) Modifications of conolidine have resulted in variable improvement in binding efficacy. This binding ultima… Read More